For which condition is Rho(D) immune globulin primarily indicated?

Rho(D) immune globulin is primarily indicated for Rh incompatibility, a condition that can arise when an Rh-negative mother carries an Rh-positive fetus. If the fetal blood cells enter the maternal circulation, the mother's immune system may produce antibodies against the Rh factor, which can lead to hemolytic disease of the newborn in subsequent pregnancies. Rho(D) immune globulin works by preventing the formation of these antibodies in the mother.

This immunoglobulin is given to Rh-negative mothers around the 28th week of pregnancy and again after delivery if the newborn is found to be Rh-positive. The administration of Rho(D) immune globulin is crucial in managing this condition effectively, thereby protecting future pregnancies and the health of the newborn.

The other options listed do not relate to Rho(D) immune globulin's indications. Uncontrolled hypertension, gestational diabetes, and severe edema are conditions that require different types of management and medications that do not involve this specific immunoglobulin therapy.