Which drug may cause tooth and bone anomalies as a teratogenic effect?

Tetracycline is known to cause tooth and bone anomalies as a teratogenic effect, particularly when administered during pregnancy. This class of antibiotics has a high affinity for calcium, which leads to the binding of the drug in developing bones and teeth. Consequently, it can result in permanent discoloration of the teeth and may affect bone growth and development, making it contraindicated in pregnant women, nursing mothers, and children under the age of eight.

In comparison, other antibiotics such as amoxicillin, penicillin, and cephalexin do not exhibit the same level of risk for teratogenic effects on teeth and bones. They aim to treat bacterial infections without the associated risks seen with tetracycline. The understanding of tetracycline's specific effects on dental and skeletal development highlights the importance of careful drug selection in pregnant individuals to minimize risks to fetal development.